| Place Name | Mayo |
| Place Type | Town |
| ZIP Code(s) | 32066 |
| County | Lafayette County |
| Area Code(s) | 386 |
| Timezone | Eastern Daylight Time (EDT) |
| Population (2022) | 1,510 |
| Population Growth Rate (2010-19) | -14.71% |
| Majority Ethnicity | African American 45.11% |
| US Congressional District(s) | Florida 2nd |
| State House Districts | 7 |
| State Senate Districts | 5 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 39.51% |
| African American | 45.11% |
| Hispanic | 0% |
| Asian | 0% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 15.38% |